Genomic Complexity of the Variable Region-Containing Chitin-Binding Proteins in Amphioxus
نویسندگان
چکیده
منابع مشابه
A role for variable region-containing chitin-binding proteins (VCBPs) in host gut-bacteria interactions.
A number of different classes of molecules function as structural matrices for effecting innate and adaptive immunity. The most extensively characterized mediators of adaptive immunity are the immunoglobulins and T-cell antigen receptors found in jawed vertebrates. In both classes of molecules, unique receptor specificity is effected through somatic variation in the variable (V) structural doma...
متن کاملExpression of Ciona intestinalis Variable Region-Containing Chitin-Binding Proteins during Development of the Gastrointestinal Tract and Their Role in Host-Microbe Interactions
Variable region-containing chitin-binding proteins (VCBPs) are secreted, immune-type molecules that have been described in both amphioxus, a cephalochordate, and sea squirt, Ciona intestinalis, a urochordate. In adult Ciona, VCBP-A, -B and -C are expressed in hemocytes and the cells of the gastrointestinal tract. VCBP-C binds bacteria in the stomach lumen and functions as an opsonin in vitro. I...
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چکیده ندارد.
15 صفحه اولThe amphioxus genome provides unique insight into the evolution of immunity.
Immune systems evolve as essential strategies to maintain homeostasis with the environment, prevent microbial assault and recycle damaged host tissues. The immune system is composed of two components, innate and adaptive immunity. The former is common to all animals while the latter consists of a vertebrate-specific system that relies on somatically derived lymphocytes and is associated with ne...
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ژورنال
عنوان ژورنال: BMC Genetics
سال: 2008
ISSN: 1471-2156
DOI: 10.1186/1471-2156-9-78